I've just run into an issue with FME Desktop crashing on startup with the system error logs mentioning winspool.drv. I'm pretty sure it is to do with a recent Windows update KB4541329 so I'm trying to uninstall that. I'll update this post once that is done but in the mean time you might want to avoid that update.
Update: Uninstalling that Windows update worked and FME Desktop runs now.