FME Server uses Distinguished Name (DN) to associate a user with Active Directory. The DN name is a composite of many AD components and is not fixed (e.g. CN=Jeff Smith,OU=Sales,DC=Fabrikam,DC=COM). Therefore if there orgnaisation unit changes or is renamed, or they marry and change there surname, etc, etc the link will be broken between FME Server and Active Directory. They will be no longer able to access FME Server, although they will still be listed as a user. I have seen this occur in many organisations.
I believe a better approach is to use the Active Directory SID which I do not believe changes for a user, and is unique to a domain. The other component to use would be a domain, as there may be more than one domain connected to FME Server. This way we would maintain a consistent link that is not affected by most AD changes.