There is only a small caveat if you use FME 64-bit - when you attempt to select a dataset with the GUI (i.e. the triple ellipsis GUI button) you will receive the following error message: "Selecting layers is only available on 32-bit editions of FME because it requires an ESRI Desktop ArcObjects product to be installed and licensed."
To work around this using FME 64-bit you must supply the full path to the dataset of interest including the extension.