Are you able to check the log? My only guess would be some kind of Authentication and/or firewall issue.
Thanks for the response. The log in Event Viewer shows an “Action Failed” with
Task Scheduler failed to complete task "\Microsoft\Windows\CertificateServicesClient\KeyPreGenTask" , instance "{af9771d5-5594-4cf4-8a75-75aadf082da2}" , action "NGC Pregeneration Task Handler" . Additional Data: Error Value: 2148073520.
and “Action Start Failed” with
Task Scheduler failed to start instance "{af9771d5-5594-4cf4-8a75-75aadf082da2}" of "\Microsoft\Windows\CertificateServicesClient\KeyPreGenTask" task for user "NT AUTHORITY\SYSTEM" . Additional Data: Error Value: 2148073520.
I’ll check with my IT team now.
Thanks again.
Regards,
Josh
I ended up opening FME under the service account and realise the SQL connections needed recreating with the Windows logon for that account, plus I one of the tables I had to drop and then run the job under this account to recreate it. The fact that it was created under my SQL login must have meant the service account couldn’t drop it to recreate it.
Thanks,
Josh
@joshuajames1979 Glad you got that working. I just ran into something similar. Trying to diagnose now. Gremlins 
Yes it can be mystery sometimes. I'm scared to make any tweaks.
I resolved my issue today. All of a sudden I was getting an an error in flow about not being able to access fgdb at a shared file location. Said make sure has not been saved in a newer version. ArcObjects error -1.
Turns out the service account had been removed from the User Group granting read/write privs to that location. Gremlins.