There are a number of transformers, which even in FME Desktop 2020.2 still rely on Python 2.7.
It was initially announced in 2008 that Python 2 would be sunsetted in 2015. A 7 year lead time. Then, in 2014 is was announced that the sunset would be changed to January 2020 - a whopping 12 years after the initial announcement. Many of our data science tools and external libraries that we wrap in for big data processing have, for some time, required Python 3 in order to operate and take advantage of all the interpreter and speed improvements (particularly with Cython, etc).
Mixed Python versions are no longer acceptable. Please get the transformers etc upgraded, tested, and compliant with Python 3. At this stage, preferably with Python 3.9 or newer.
Example:
GZipDecompressor
GZipCompressor