Fatal Python error: Py_Initialize: unable to load the file system codec

Hi @romainttqib

If you wish to use ArcGIS Pro's interpreter, please set the workspace's Python Compatibility parameter in the Navigator pane to Esri ArcGIS Python 3.6. Depending on the FME version used, the exact wording of the parameter choice may be different.

Please clear the options set in Tools > FME Options > Preferred Python Interpreter. It is not necessary to set the Preferred Python Interpreter setting in order to use Esri's Python interpreters in recent versions of FME.

I had this problem as well. Because of the incompatibility of the FME version I am using (2020.0.2) with the ArcGIS Pro Version (2.6.3), the Python Compatibility to ESRI ArcGIs Pro Python 3.6 did not work for me and I had to use a different solution.

For me the solution was like this:

1. In the workspace Parameters - Scripting set the Python Compatibility to Python 3.6+
2. In Workbench - FME Options - Translation Settings set Python Interpreter to "C:\\Program Files\\ArcGIS\\Pro\\bin\\Python\\envs\\arcgispro-py3\\python36.dll"
3. In Workbench - FME Options - Translation Settings set Python Home to "C:\\Program Files\\ArcGIS\\Pro\\bin\\Python\\envs\\arcgispro-py3"
4. Check the System Environment variables and ensure there are no PATH or PYTHONPATH variables pointing to a different or older version python
5. Add a PYTHONPATH environment variable like this "C:\\Program Files\\ArcGIS\\Pro\\bin\\Python\\envs\\arcgispro-py3;C:\\Program Files\\ArcGIS\\Pro\\bin\\Python\\envs\\arcgispro-py3\\Lib;C:\\Program Files\\ArcGIS\\Pro\\bin\\Python\\envs\\arcgispro-py3\\Lib\\site-packages"

You will need to sign out and in of your machine for the Environment Variables to take effect.